Multiple Painful Bluish Nodules on a Young Man

Glomangiomas are rare, benign vascular tumors originating from glomus cells. Clinically, they present as pink-blue nodules, painful to palpation. Histopathological examination is required for diagnosis. This clinical case represents a diagnostic challenge, highlighting the need to raise awareness of the rarity of this condition

Flattned Nose Revealing Syphilitic Aortitis

Flattled nose also called syphilis nose is a deformation of the nose due to the destruction of the cartilage of the nasal septum : the lower segment of the nose collapses, undergoing recoil and retract, becoming embedded in the upper segment. It is characteristic of congenital and tertiary syphilis. We report the case of syphilitic aortitis revealed by flattened appearance of the nose.

Unilateral Localized Bullous Pemphigoid Associated with Chronic Venous Stasis: A Case Report

Localized Bullous Pemphigoid (LBP) is a rare form of Bullous Pemphigoid (BP), it is usually related to trauma and can appear on any wound or surgery site. Chronic venous stasis has not been described as a predisposing factor. We present the case of an 80-year-old Hispanic man with a previous history of chronic venous stasis and surgical intervention in both legs, who presented with a unilateral form of LBP, initia...

An Atypical Case of Wolf’s Isotopic Response Manifesting as Bullous Pemphigoid in a Patient with Longstanding Psoriasis Vulgaris

Wolf’s isotopic response refers to the occurrence of a new, unrelated skin disorder over areas of skin which were previously affected by another skin disorder. To date, a case of Wolf’s isotopic response in a patient with psoriasis vulgaris as the primary dermatological condition has yet to be reported. We describe an occurrence of Wolf’s isotopic response in a 72-year-old patient with longstanding psoriasis vulga...

Basal Cell Carcinoma in a Construction Worker: Occupational Medicine and Exposure Prevention

Occupational dermatoses are skin disorders caused by workplace exposure. The authors report the case of a construction worker whom, during routine evaluations, while performing medical surveillance, presented a pearly papule of hyperemic appearance located between the medial margin of the left eye and the bridge of the nose. The suspicion was of Basal Cell Carcinoma (BCC). The worker was sent by the occupational p...

Mixed Eyelid Lesion: Seborrheic Keratosis on Basal Cell Carcinoma with Heterogeneous Pattern

Mixed, contact or coexisting skin lesions attract a lot of attention from the clinician and have been the subject of multiple references in the literature. Sometimes these are morphological curiosities without therapeutic or prognostic repercussions. However, there are cases in which its diagnosis involves a different way of proceeding after the diagnosis. We present a case of basal cell carcinoma hidden under seb...

The Experience as Dermatologists in the Emergencies COVID-19 “Pandemic Hospital”: Subacute and Chronic Cutaneous Manifestation of COVID

The Hospital of Emergencies Enfermera Isabel Zendal, constructed during the Covid 19 pandemic crisis, is a public hospital that supports the hospital network of the Madrid health service. It is also known as the “Pandemic hospital” and was designed for use in the event of emergencies, health crises or health care need. This hospital represents a new concept of hospitalization and has a maximum capacity of 1000 bed...

Enhancing Cosmesis While Achieving High Cure Rates for Early Stage Non-Melanoma Skin Cancer in the Outpatient Dermatology Clinic Using a Novel Non-Invasive Modality

Introduction: Non-Melanoma Skin Cancer(NMSC) is generally treated in dermatology offices using surgical techniques. Objectives: We evaluate the feasibility, tolerance, effectiveness and cosmesis using an office-based non-surgical modality for NMSC. Methods: 93 patients with 133 pathologically confirmed early stage invasive and insitu NMSC lesions treated with Image-Guided Superficial Radiation Therapy (IGSRT) were...

Calcifying Basal Cell Carcinoma. Another Example of Calcinosis Cutis in a Neoplasm?

With basal cell carcinoma being the most common malignancy, we should not be surprised by the fact that there are numerous morphological variants. Many of them carry a prognostic significance and have treatment implications, while others can be considered findings, sometimes simple curiosities conditioned by factors as diverse as differentiation or tissue response to the aggression that the neoplasia entails. We p...

Squamous Cell Carcinoma Arising from a Nevus Sebaceous (NS) of the Scalp

In adulthood, Nevus Sebaceous is frequently associated with the development of benign and malignant neoplasms and depending on the location and size, the sebaceous nevus can cause aesthetic problems. We report the case of a 52-year-old man who had a Nevus Sebaceous, size 3.0 X 2.8 cm, in the left parietal side that developed a partially hyperkeratotic evolution in few months. The lesion was removed by Mohs-Tubinge...

Dupilumab Treatment in Adult Onset Atopic Dermatitis

Topical Photodynamic Therapy (PDT) applications have been increasing on dermatological fields on skin diseases as well as in cosmetic procedures. Currently, PDT in dermatology for cosmetic procedures using 5-aminolevulinic acid (ALA) for application is done in elevated concentrations and often is followed by several side effects due to elevated inflammatory process. However the inflammatory response level depends...

Topical Photodynamic Therapy Using 5-Aminolevulinic Acid (Ala) for Cosmetic Purposes on Aesthetic Procedures

Topical Photodynamic Therapy (PDT) applications have been increasing on dermatological fields on skin diseases as well as in cosmetic procedures. Currently, PDT in dermatology for cosmetic procedures using 5-aminolevulinic acid (ALA) for application is done in elevated concentrations and often is followed by several side effects due to elevated inflammatory process. However the inflammatory response level depends...

Two Novel Mutations in a Zinc Transporter Gene Slc39a4 in Patients with Acrodermatitis Enteropathica

Background: Acrodermatitis Enteropathica (AE) is a rare autosomal recessive disorder, characterized by severe zinc deficiency. The human AE gene, SLC39A4 encodes the zinc transporter hZIP4. A large number of different mutations of the SLC39A4 gene have been identified in AE. Objective: We received blood samples from four families of AE for the determination of the molecular basis of this disorder. Design: We utili...

Breast cysts and aluminium-based antiperspirant salts

On the basis that aluminium-based antiperspirant salts are designed to block apocrine sweat ducts of the axilla, and that breast cysts result from blocked breast ducts in the adjacent region of the body, it has been proposed that breast cysts may arise from antiperspirant use if sufficient aluminium is absorbed into breast tissues over long-term usage. This review collates evidence that aluminium can be absorbed f...

Treatment of Atopic Dermatitis: What’s New?

Atopic dermatitis is a common and chronic skin disorder among the children and adults. The treatment guideline that was recently accepted in Europe includes dupilumab, a monoclonal antibody, along with the conventional treatment methods. In addition to dupilumab, other monoclonal antibodies have been developed and their efficacies were evaluated with randomized controlled trials. These antibodies are nemolizumab,...

Treatment of Atopic Dermatitis: What’s New?

Atopic dermatitis is a common and chronic skin disorder among the children and adults. The treatment guideline that was recently accepted in Europe includes dupilumab, a monoclonal antibody, along with the conventional treatment methods. In addition to dupilumab, other monoclonal antibodies have been developed and their efficacies were evaluated with randomized controlled trials. These antibodies are nemolizumab,...

Inflammatory Breast Cancer; Diagnostic and Therapeutic Challenges

Inflammatory Breast Cancer (IBC) is an aggressive form of breast cancer with dermal manifestations. This is due to the direct effect of the breast cancer cells which block the lymphatic channels of the skin. Consequentially, it appears to have an inflammatory appearance of skin overlying the breasts. Hence, it can often be confused with infection of the breast and may cause diagnostic challenges to clinicians as m...

The Effect of Local Botulinum Toxin A Injections in Long-Term Management of Chronic Pain in Post- Herpetic Neuralgia: Systematic Review and Case Reports Treated With Incobotulinumtoxin A

Back ground: Botulinum toxin A (BoNT A) may be helpful in modulating severe chronic neuropathic pain in Post-Herpetic Neuralgia (PHN). Method: Clinical studies and case series were searched with term “neuropathic pain” and “botulinum” on PubMed to 28. Feb. 2019. Pain was measured with Visual Analogue Scale (VAS) at baseline and at follow–up after BoNT A therapy. Results: As result 6 cases /case series and 8 studie...

Evaluation of the Stimulating and Protective Effects of Fucoxanthin Against Human Skin Fibroblasts: An In Vitro Study

Some plant–derived preparations become increasingly popular in treating unfavorable skin conditions, enhancing beauty and promoting wellness. Active ingredients extracted from marine algae, which are part of the traditional Asian diets and remedies, are actively studied in this respect in recent years. Fucoxanthin (FX), an orange–colored xanthophyll derived from edible brown seaweeds, is among the most intensively...

Photobiomodulation and Photodynamic Cosmetic Therapy on Hair Growth: Case Report

Androgenetic alopecia is a hereditary condition form of hair loss in both men and women. Among the established treatments of alopecia, the treatment based on pharmaceuticals drugs and laser, both with well-established satisfactory results, stand out. The association of light (laser and/or LED) to conventional Cosmetic Procedures in the Treatment of Alopecia optimizes the results minimizing the need for the associa...

A Case of Lentiginosis Associated with LEOPARD Syndrome

Noonan Syndrome with multiple lentigines (formerly called LEOPARD syndrome) is a rare hereditary disorder. It is mainly characterized by skin, facial and cardiac anomalies. LEOPARD is an acronym for the major features of this disorder, including multiple Lentigines, Electrocardiogram (ECG) conduction abnormalities, Ocular hypertension, Pulmonic stenosis, Abnormal genitalia, of growth Retardation and sensorineural...

Effectiveness of the Association of Cellulose Membrane Dressing and Photodynamic Therapy Mediated by Curcumin to Reduce Contamination and Prevent Recontamination in Pressure Lesions

The aim of this study was to isolate the main contaminating microorganisms from pressure lesions (PLs) and to evaluate the effectiveness of cellulose membrane and Photodynamic Therapy (PDT) mediated by curcumin in its combat and prevention of recontamination in hospitalized patients. Twelve PLs from seven patients were treated with two sessions of PDT, with 7 days interval, mediated by curcumin in 1.5% emulsion an...

Diabetes and the Skin

The prevalence of diabetes mellitus constantly increased during last year’s reaching impressive figures and next decades will reserve to us a further escalation. Developing countries, until now almost spared from this pandemia, will become the centre of new disease development and younger groups of population will observe their already reduced life expectancy reduced further. World Health Organization has therefor...

Oculodermal Melancytosis, the Nevus of Ota Histopathology Highlights

Oculodermal Melancytosis/ nevus of Ota a rare congenital disorder has intrigued, because of its cardinal clinical connotation in addition to histopathology highlights, emphasizing sparing of the epidermis, the blunt of disease is borne by the dermis evidence as prominent sebaceous lobules of the facial skin in addition to many slender, dendritic, pigmented melanocytes arranged horizontally between / entrapped amon...

Leprosy Revisited

Leprosy [1] is a chronic granlomatous disease involves skin peripheral nerves, nasal mucosa affecting tissues and organs. Demonstration of Causative Organism through Slit -Skin smear Examination [2] Mycobacterium leprae / M. leprae (Figure 1) Ziehl-Neelsen stain Acid fast bacilli. Narrative of M. leprae including its characteristics, mode of transmission pathogenesis, and evolution of classification are salient pr...

Acquired Tufted Angioma(s): A Clinicopathological Entity

Acquired angiomas, vascular tumors perse has thus far been sporadically reported [1,2], because of its asymptomatic nature despite explicit clinicopathological features. The current report is an attempt to focus attention on these aspects, enriching through clinical as well as histological illustrations. A 30-year-old woman presented with reddish, nodular lesions scattered around the left eye, (Figure 1) for the p...

Vitiligo, Rheumatoid Arthritis and Pustular Psoriasis: A Rare Presentation

A 44 year male presented with joint pains, hypopigmented macules over extremities and trunk, finger and toe deformities and pus filled lesions over macules. A detailed clinical and laboratory examination revealed a combination of rheumatoid arthritis, vitiligo and pustular psoriasis. Multiple autoimmune syndrome described as the occurrence three or more autoimmune conditions simultaneously or sequentially. The rar...

Expression of Laminin 332 in Vesicant Skin Injury and Wound Repair

Sulfur Mustard (SM) is a potent vesicant or blistering agent. It is a highly reactive bi-functional alkylating agent that cross links proteins, DNA, and other cellular components. Laminin 332 is a heterotrimer glycoprotein and a crucial skin component that attaches the epidermal basal keratinocytes to the dermis. SM wounds histologically appear similar to Epidermolysis Bullosa (EB), human genetic blistering diseas...

Photodynamic Therapy with 5-Aminolevulinic Acid (ALA) in the Treatment of Acne: A Case Study

Photodynamic Therapy (PDT) is characterized by a combination of a photosensitizing compound that is retained in the tissues, followed by illumination with light, which causes a photoreaction. Its action occurs mainly through mechanisms of energy transfer between the excited Photosensitizer (PS) and the molecular oxygen present in the tissues generating reactive oxygen species, with possible reactions with the tiss...

Diagnosis of Bacillary Angiomatosis and Kaposi´s Sarcoma in the same Skin Lesion in a Patient with Recent HIV/AIDS Diagnosis

Kaposi´s Sarcoma (KS) is polyclonal multifocal disease of endothelial origin, with four clinical and epidemiological well described variants. AIDS-related KS has a variable clinical course, ranging from minimal disease located to the skin and presenting as an incidental finding to a rapidly progressing neoplasm with skin, mucosal, and visceral compromise that can result in significant morbidity and mortality, depe...

Management of Cicatricial alopecia by Hair transplantation using follicular unit extraction

Hair transplantation by Follicular Unit Extraction (FUE) has been commonly used in androgenetic alopecia but there is comparatively less experience with cicatricial alopecia. In this article we have discussed and reviewed various factors influencing the modality of surgical treatment in cicatricial alopecia. Although there have been many speculations about viability and results, we have noted successful results by...

Sclerosingpanniculitis: The Significance of Confirming Venous Insufficiency Through Ultrasonography

Sclerosingpanniculitis is a chronic fibrosing process by inflammation of the subcutaneous fat, and indurated, inflamed plaques on the lower extremities. There current standard lacks specific therapeutic guideline for treating sclerosingpanninculitis while variable efficacy of treatment options has been reported. The disease has been associated with other venous abnormalities, such as chronic venous insufficiency,...