Diazoxide Toxicity in Congenital Hyperinsulinism: A Seldom-Considered Rare Side Effect

Diazoxide is the sole approved drug for congenital hyperinsulinism; however, diuretic administration and vigilant monitoring are crucial to prevent and promptly identify potentially life-threatening adverse effects. This report aims to highlight a seldom considered rare side effect of diazoxide.

Clinical and Paraclinical Metabolic Outcomes in Patients with Pheochromocytoma

Background and aim: Pheochromocytoma is a rare endocrine tumour that originates from the chromaffin cells of the sympathetic and parasympathetic nervous system. Pheochromocytoma has been called the "Great Mimic" because its clinical manifestations range from an adrenal gland accident to hypertensive crises with associated cerebral or cardiovascular complications. Patients and Methods: A total of 70 patients were i...

SGLT2i Induced Refractory Mycotic Infections.. Organ vs Tissue

SGLT2 inhibitors are first among the anti-hyperglycemic agents to have demonstrated a significant impact on the cardio-renal complications of diabetes and have been quickly incorporated into guideline recommendations as agents for preferential use irrespective of HbA1C in patients with established ASCVD or risk for ASCVD, heart failure & CKD with proteinuria, in the last two settings with or without diabetes [1]....

Role of Community Health Workers in Glycemic Control in Hispanic Patients with Type 2 Diabetes

Background: The role of Community Health Workers (CHW) in diabetes control among Hispanic patients with type 2 diabetes is unclear. Objective: To clarify the impact of CHW on diabetes control in Hispanic patients as reflected by hemoglobin A1c (HbA1c) values in randomized controlled trials conducted in the USA. Methods: Pubmed search until December 1st, 2021. Search terms are community health workers, peer leaders...

Effect of Zinc Supplementation on Renal and Sexual Function of Men with Diabetic Nephropathy and Impotence, a Randomized Double-Blind Cross Over Clinical Trial

Background: Free radical generation and oxidative stress has been hypothesized to be underlying pathogenesis of diabetic complications like nephropathy and erectal dysfunction. Zinc can reduce lipid per-oxidation and improves endothelial functions. Objectives: In this study, we evaluated the effects of Zinc supplementation on the renal and sexual function of men with Type 2 diabetes. Methods: The study registry co...

Gender and Immunosenescence Dependent Progression of COVID-19 Disease in Bangladeshi Population

Novel coronavirus, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) emerged from Wuhan, China has spread rapidly around the world with a male bias case fatality rate. The highly infectious Corona Virus Disease 2019 (COVID-19) pandemic caused by the SARS-CoV-2, quickly surges in Bangladesh and the case disaggregated epidemiological data also showed that men, especially the aged men have higher risk of d...

Molecular Association of Diabetes Mellitus with Different types of Cancer from Population of Lahore

Million people die of diabetes and different types of cancer every year. Current study include effects of major risk factors, as hyperglycemia and obesity are novel risk factors contributing both cancer and diabetes and biochemical pathways in association with these two diseases. Diabetes mellitus can enhance risk of a varied range of tumors, for instance pancreas, liver, early gastric, lung, prostate, breast, acu...

Dipsogenic and Gestational Diabetes Insipidus

Study of central polydipsia and gestational Diabetes Insipidus (DI) provides a simple and comparative model for additional assessment of hypothalamic-pituitary control upon water metabolism where degrees of unbalance are usually less intense, short timed and varied as is the case of normal pregnancy or in association to hypertensive disease where dramatic changes in intravascular volume and vascular resistance occ...

Electroretinographic Findings of Patients with Long Duration Diabetes but No Retinopathy: A Pilot Study Using a Handheld RETeval-DR™ Device

Aims/hypothesis: Diabetic retinopathy is usually considered as a microvascular disease, but neurophysiological abnormalities of the retina occur early and have been postulated to play a role in the pathogenesis of diabetic retinopathy. However, a causal relationship has not been established. Hitherto, specialized equipment and facilities have been required for studying this aspect of retinal changes in diabetes. R...

Influence of Vitamin E on the Reproductive Capacity and Fetal Development in Obese Rats

Prenatal obesity has been associated with a higher incidence of congenital defects, impairment of reproductive capacity and fetal development of the offspring. The increase of free fatty acids, reactive oxygen species and other mediators of cellular communication mediate the disorders in the evolution and results of pregnancy. Vitamin E for its antioxidant action seems to be a therapeutic candidate that relieves t...

Continuous Glucose Monitoring Functions as a Negative Feedback Loop for Individuals with Type 2 Diabetes

To maintain homeostasis, the body employs negative feedback loops that track the current state of a system and trigger regulatory responses when certain thresholds are exceeded. Monitoring current status typically employs processes that trigger either endogenous or exogenous regulatory responses, such as low blood pressure triggering heart rate acceleration or hunger triggering eating. In the case of diabetes, eug...

Evaluation of a Weekly Physician-Driven Bolus Titration Algorithm in Patients with Type 2 Diabetes Prescribed V-Go® Wearable Insulin Delivery Device for Basal-Bolus Therapy

Aims: Insulin therapy remains the cornerstone for treatment of type 2 diabetes mellitus (T2DM), and basal-bolus administration usually requires multiple daily injections. Non-adherence to the treatment regimen and failure to achieve target A1C levels are common. To overcome this dilemma, a study evaluated V-Go a 24-hour wearable basal-bolus insulin delivery device using a physician-directed insulin bolus titration...

Biomolecular Evaluation of Cobalamin (Vitamin B12) in the Diabetic Population of Lahore and Sheikhupura

Aims: Many efforts are being made in Pakistan to decrease the incidence of Diabetes and diabetic complications. These efforts are therapeutic cure and therapeutic prevention of Diabetes. One of these efforts is to work on Vitamins. The purpose of our research is the Biomolecular Evaluation of Vitamin B12 in the Diabetic population of Lahore and Sheikhupura. Methods: The serum samples of diabetics and normal health...

Analysis of Pyridoxine in the Male Diabetic Population of Lahore and Sheikhupura

Pyridoxine is an important vitamin involved in metabolism, and its deficiency can lead to serious diseases among which diabetes is a common one. In the present research work, the aim is to compare pyridoxine level between diabetic patients of Punjab University Lahore premises and D.H.Q hospital Sheikhupura. 100 samples of diabetic patients and 50 samples of normal healthy controls are collected from PU Lahore prem...

Linkage of Micro Albuminuria and Serum Albumin Levels in the Diabetic Patients of Punjab University Premises

Microalbuminuria and serum albumin levels both are associated with an increased risk of cardiovascular and renal disease in patients with diabetes and hypertension. The role of microalbuminuria as a predictor protein biomarker of diabetes nephropathy and heart disease has not been examined in large general-population of Pakistan, and its prognostic significance in persons with established diabetes is uncertain. In...

Anthropometry in Elderly Mexican Patients with Diabetes Treated with Insulin or Hypoglycemic Agents

Objectives: To evaluate Anthropometry in elderly Mexican patients with diabetes treated with insulin or hypoglycemic agents. Material and Methods: Cross-sectional study. Secondary analysis of the multicenter SABE study who had the following measures: height, weight, waist and hip size, treatment with insulin or hypoglycemic agents.It was analyzed the frequency distribution, percentages, ranges, standard deviation,...

Evaluation of Treatment of Diabetic Complications like Neuropathy, Nephropathy & Cardiomyopathy in Rats by Combination Therapy of Ethanol Extract of Senna Auriculata Leaf, The Phyllanthus Emblica L. Fruits and Syzygium Cumini (L.) Skeels Seeds on Used to Treat Diabetes in Tribes of Telangana State

Purpose of research: India is “diabetes capital of the world”. Diabetes Atlas 2006: Rise to 69.9 million by 2025 unless urgent preventive steps are taken, considered major causes of morbidity and mortality.

Childhood obesity, diabetes Mellitus and Cardiovascular Consequences

Diabetes Mellitus (DM) is an epidemic of worldwide proportion, and especially in developed coun tries. DM has many adverse consequences from related diseases that include hypertension, mac rovascular and microvascular disease, pancreatic islet cell loss and hyperglycemia, renal impair ment leading to end stage renal disease. While Type 1 diabetes has long been known as a disease of childhood with an autoimmune mec...

pathogenic Mechanisms for outer Retinal Layer Changes in diabetic Retinopathy

Diabetic Retinopathy, primarily a disease of the retinal vasculature, is a major public health problem, being responsible for more irreversible blindness than any other pathology in middle and older age people. The underlying pathogenic mechanisms are not clearly understood. In this study we aim at studying the role of Intercellular Adhesion Molecule (ICAM-1) and its inter action with Vascular Endothelial Growth F...

An Unusual Case of a Teenager with Diabetes

Double diabetes or Hybrid Diabetes (HD), presenting in childhood and adolescence, includes characteristics of T1D, positive Diabetes Associated Auto-antibodies (DAA), and T2D, obesity and insulin resistance, and also positive family history of T1D and T2D. It is characterized by a rapid beta cell failure. Due to the increasing prevalence of childhood obesity, the possibility of the presentation of unusual types of...

Pre-Pregnancy Diabetes and Obesity Increase Synergistically the Risk of Caesarean Delivery in Indigenous Australians from North Queensland Communities

Objectives: To quantify the risk of Caesarean Delivery (CD) for pre pregnancy diabetes among Australian Indigenous women in North Queensland. Methods: Cohort study including 298 women who delivered babies in hospitals between 1998 and 2008 and who had pre-pregnancy measures from 1998-2002. Baseline measures included weight, height, waist circumference, blood pressure, fasting glucose, lipids, red cell folate, urin...