Profile of the Asthma Patient Monitored in the Pneumology Department of the Saint-Louis Regional University Hospital in the African Sahelian Zone

Introduction: Asthma is a chronic disease which today constitutes a public health problem. In Senegal, the prevalence of asthma has not yet been assessed. The objective of this work was to determine the profile of asthma in the Saint-Louisian environment in the African Sahelian zone. Material and methods: This was a prospective cross-sectional descriptive study spread over a period of 12 months. The population con...

Laparoscopic Adrenalectomy for Metastatic Disease

Adrenal surgery for metastatic disease is unfrequently performed. Pooled analyses showed a survival benefit and adrenal surgery in this setting is a validated procedure in the endocrine and oncology guidelines. Respecting the rules for open surgery (safety and R0 surgery), laparoscopic adrenalectomy also combines the advantage of minimal invasive procedure in patients with decreased performance status. We reviewed...

Central Nervous System Involvement in Patients with AIDS-Associated Histoplasmosis

Central Nervous System (CNS) histoplasmosis is a rare manifestation of the Histoplasma capsulatum infections, often misdiagnosed due to the wide spectrum of neurological presentation. CNS histoplasmosis occurred most often in immunocompromised individuals, but some patients were previously, healthy. The diagnosis can be established by culture and antigen and antibody testing of the cerebrospinal fluid. Treatment w...

Organizing Pneumonia- Review of Clinical and Radiographic Findings, Treatment and Outcomes

Organizing Pneumonia (OP) is a clinical condition associated with a histopathologic pattern of lung repair that results from alveolar damage and characterized by a patchy filling of alveoli and bronchioles by loose plugs of connective tissue. Organizing pneumonia is classified as either Cryptogenic OP (COP), which has no specific etiology, or Secondary OP (SOP) which can be associated with a multiplicity of causes...

A Man behind a Syndrome: Who was Doctor Zivert?

The article is devoted to biography of A.-F.-J. K. Zivert (1872-1922), a Russian physician of German ethnic origin, who lived in the Silver Age (a period in the History of Russian culture between 1890 and early 1920ies). Dr. Zivert made early, significant and internationally recognized contribution into medical science and became eponymous. A-F.-J. K. Siewert (aka: Zivert, Ziwert, von Siewert) is known for first d...

Circulating miRNAs as Prospective Biomarker for Progressive Pulmonary Fibrosis in Comparison with Surfactant Protein D in Mice

As for the serum biomarkers clinically available for progressive pulmonary fibrosis including idiopathic pulmonary fibrosis, Surfactant Protein D (SP-D) and Krebs von den Lungen-6 antigen (KL-6) have been used for more than 20 years in Japan not only for supporting diagnosis but detecting the disease progress. However, both of these markers are produced chiefly by alveolar type II epithelial cells, which might ind...

Cicatricial Variant of Organizing Pneumonia: A Case Description and Literature Review

The cicatricial variant of organizing pneumonia (CCOP) is a distinct morphological manifestation of organizing pneumonia. It may present with shortness of breath, dyspnea on exertion, and dry cough. Imaging is variable, ranging from localized to multifocal disease, and manifesting as ground glass, linear, or reticulonodular infiltrates. Histologically, unlike classical OP, the fibromyxoid plugs of CCOP undergo fib...

Noninvasive Management of Ventilatory Pump Failure

Introduction and Objectives Until resorting to tracheotomy became popular in the late 1960s, all ventilator dependent people were managed noninvasively, that is, by body ventilators until 1953 then subsequently, by noninvasive intermittent positive pressure ventilatory support (NVS) delivered via 15 mm angled mouthpieces during the daytime and mouthpieces with lip cover phalange for sleep [1]. When patients develo...

Influencing Factors of Forced Expiratory Volume for Lung Cancer Patients

Surgery plays a principal role in the exact management, diagnosis and staging of non-small cell lung cancer. Lung resection offers the most probable of cure for localized primary lung cancer patients, which is highly associated with mortality, a risk of decreased postoperative lung function, and other complications [1,2]. One of the most fundamental criteria of fitness for lung resection surgery is a preoperative...

Recurrent Acute Pancreatitis Secondary to Alpha-1-Antitrypsin Deficiency

We present the first reported case of recurrent acute pancreatitis occurring with alpha-1-antitrypsin deficiency (PI*ZZ phenotype). Despite evidence of a clinically significant association between alpha-1-antitrypsin deficiency and other inflammatory diseases, the literature surrounding the causal relationship with pancreatitis is less well-documented and currently remains inconclusive. It is important to explore...

Atypical Manifestations of Tuberculous Pleural Effusions

Typically, a tuberculous pleural effusion is submassive, unilateral, and has the appearance of being straw coloured, and a cellular content which is predominantly lymphocytic. Atypical stigmata do, however, have to be recognised, so as to mitigate the risk of diagnostic delay, the latter sometimes resulting in potentially avoidable deaths and risk of transmission of tuberculosis to close contacts.

Does Hyperthermic Intrathoracic Chemotherapy Prolong Survival in Patients with Pleural Thymoma? – A Systematic Review of the Literature

Introduction: Thymoma with pleural spread, whether de novo or in form of pleural relapse after surgical resection, is a difficult to treat disease. Hyperthermic intrathoracic chemotherapy (HITHOC) has recently been increasingly discussed as a possible beneficial adjunct to cytoreductive surgery with the aim of reducing pleural recurrence and prolonging survival in these patients. Methods: We searched the PubMed in...

Effect of Switching from eCsC to GLI Spirometric Reference Values on Gold Classification of Severity of Airflow Obstruction

Introduction: GOLD recommends to classify COPD severity of airflow obstruction according to the post bronchodilator FEV1 expressed as a percentage of the predicted value. GOLD also recom mends to use the clinical classification based on dyspnea severity and exacerbation risk. How ever, in some countries like Belgium, the reimbursement of some COPD medicines is based on the GOLD spirometric classification. The repl...

Synthesis and In Vitro Evaluation of Iron Cross Linked Alginate Nano Particle for Controlled Drug Release

Highly stable Iron cross linked alginate nano particle was prepared via Ionotropic gelation method using natural honey as stabilizer. The nanoparticles formed were characterized by Fourier Transform Infrared Spectroscopy (FT IR), which confirmed the formation of iron cross link between alginate chains. Dynamic Light Scattering (DLS) and Transmission Electron Microscopy (TEM) imaging revealed the formation of spher...